American Society for Transplantation and Cellular Therapy (ASTCT) Job Connection

Medical Director

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Jasper Therapeutics
Redwood City, California, United States
2 days ago


Reports To: SVP, Research and Translational Medicine

Location:     San Francisco Bay/Peninsula

Jasper Therapeutics is a publicly listed company with a lead clinical-stage program that is a first-in- class and potentially breakthrough antibody to safely replace chemo-radiation as a conditioning agent for diseases for which hematopoietic cell transplants (HCT) of allogeneic or gene-modified cells are the only known curative therapy. These diseases include (but are not limited to) acute myeloid leukemia, myelodysplastic syndrome, rare genetic blood diseases such as primary immune deficiency diseases and hemoglobinopathies such as sickle cell disease. Jasper is also developing a novel cell engineering platform focused on transiently modifying hematopoietic stem cells to significantly improve the efficacy and safety of donor allogeneic transplant and gene therapies.  By creating novel, safe and highly effective conditioning regimens for hematopoietic transplantation, Jasper is leading the field with innovative clinical trials to safely bring cures to patients suffering from a variety of life-threatening diseases.

The Jasper vision is to build a leading biotechnology company to advance the field of hematopoietic cell transplantation (HCT) by leveraging its basic and translational science to generate a pipeline of innovative therapeutics in the areas of HCT conditioning, immune modulation, cell engineering and gene editing therapies.

Position Summary

Leads the direction, planning, execution, and interpretation of clinical trials of one or more Phase 1 clinical development programs at Jasper, focused on advancing JSP191 and other novel stem cell targets and molecules. Participates in and may lead cross-functional teams to generate, deliver, and disseminate high-quality clinical data supporting overall product scientific and business strategy. 


  • Leads and demonstrates ownership of the design and implementation of multiple clinical development programs in support of the overall product development plan, based on strong medical and scientific principles, knowledge of compliance and regulatory requirements, markets, business operations, and emerging issues. Oversees project-related education of investigators, study site personnel, and Jasper study staff.
  • Has overall responsibility for leading clinical study teams, monitoring overall study integrity, and review, interpretation, and communication of accumulating data pertaining to safety and efficacy of the molecule. Along with Clinical Operations, is responsible for ensuring agreed-upon study enrollment and overall timelines for key deliverables. Responsible for assessment and reporting of serious adverse events per corporate policy and regulations for those protocols on which assigned.
  • Primary responsibility for and ownership of design, analysis, interpretation, and reporting of scientific content of protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents.
  • Work collaboratively with Medical and/or Scientific Directors and Clinical Scientists working on the same or related programs.
  • Serve on Clinical Strategy Team(s), with responsibility for development of a rigorous, cross-functionally-aligned, vetted Clinical Development Plan with full consideration of contingencies and alternative approaches.
  • Serves as an in-house clinical expert for one or more molecules and diseases in the therapeutic area, coordinating and leading appropriate scientific and medical activities with internal stakeholders as they relate to ongoing projects. May participate in or lead clinical development contributions to due diligence or other business development activity. As required by program needs, contributes in partnership with Discovery colleagues to design and implementation of translational strategies.
  • Acts as clinical lead and actively solicits opinion leader interactions related to the disease area(s); partners with Medical Affairs, Commercial and other functions in these activities as required, consistent with corporate policies, to ensure that broad cross-functional perspectives are incorporated into Clinical Development Plans and protocols as appropriate.
  • Stays abreast of professional information and technology through conferences, medical literature, and other available training, to augment expertise in the therapeutic area. May represent Jasper at key external meetings.
  • Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements. Serves as a clinical representative for key regulatory discussions.


  • Medical Doctor (M.D.) or non-US equivalent of M.D. degree with relevant therapeutic specialty in an academic or hospital environment. Completion of a subspecialty fellowship is required.
  • Significant experience with trial experience in the pharmaceutical industry, academia, or equivalent.
  • Ability to run a complex clinical research program independently.
  • Proven leadership skills and ability to bring out the best in others on a cross-functional global team. Must be able to lead through influence.
  • Ability to interact externally and internally to support a global scientific and business strategy.
  • Extensive knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in development of clinical strategy and the design of study protocols.

Job Information

  • Job ID: 64036834
  • Location:
    Redwood City, California, United States
  • Position Title: Medical Director
  • Company Name For Job: Jasper Therapeutics
  • Industry: Biotechnology
  • Job Function: Other
  • Setting: Other
  • Job Type: Full-Time
  • Job Duration: Indefinite

Please refer to the company's website or job descriptions to learn more about them.

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